榆干离褶伞溶栓酶对内皮细胞损伤大鼠模型的保护作用

榆干离褶伞溶栓酶对内皮细胞损伤大鼠模型的保护作用
目的：探讨榆干离褶伞溶栓酶对肾上腺素致血管内皮细胞损伤的保护作用。方法：采用注射肾上腺素结合冰浴的方法制备大鼠血管内皮细胞损伤模型，检测血液循环内皮细胞数（CEC）和血浆血栓素B2 (TXB2)、6-酮-前列腺素E1α(6-keto-PGE1α)、组织纤溶酶原激活物（t-PA）以及抗凝酶Ⅲ(AT-Ⅲ)的含量。结果：模型组的循环内皮细胞数和TXB2水平较正常组明显增高，且t-PA和AT-Ⅲ含量下降。用药组可减少循环内皮细胞数和TXB2水平，提高6-keto-PGE1α、t-PA和AT-Ⅲ含量。结论：榆干离褶伞溶栓酶对血管内皮细胞起保护作用。

Objective: To study the protective effect of fibrinolytic enzyme from Lyophyllum ulmarium (L.u) on endothelial cell injury induced by adrenaline. Methods: Rats were injected with adrenaline and making swim in ice-cold water. Then the number of circulating endothelial cells, and the levels of TXB2, 6-keto-PGE1α, t-PA and AT-Ⅲ in plasma were measured. Results: Model group increased the number of circulating endothelial cells and TXB2, and decreased the levels of t-PA and AT-Ⅲ as compared with the normal group. The treatment group reduced the number of circulating endothelial cells and TXB2 content, increase the levels of t-PA and AT-Ⅲ as compared with the model group. Conclusion: The fibrinolytic enzyme from Lyophyllum ulmarium presents the protective effect on vascular endothelial cells.

标题：榆干离褶伞溶栓酶对内皮细胞损伤大鼠模型的保护作用
英文标题：Protective effects of fibrinolytic enzyme from Lyophyllum ulmarium on vascular endothelial cells injury in rats

作者：
王玉娇 延边大学医学院
周广亮 延边大学医学院
沈明花 延边大学医学院

中文关键词:榆干离褶伞,溶栓酶,血管内皮细胞,
英文关键词:Lyophyllum ulmarium,fibrinolytic enzyme,vascular endothelium,

发表日期：2015-10-30

榆干离褶伞溶栓酶对内皮细胞损伤大鼠模型的保护作用.pdf

文件大小:

515.83 KB

高速下载