海洋动物糖胺聚糖的研究进展
糖胺聚糖存在于大多数海洋动物的组织中, 目前主要利用酶解法进行提取, 已确定的糖胺聚糖一共有7种。因为糖胺聚糖具有高生物活性和低毒副作用的特点, 所以近年来国内外学者对海洋动物中糖胺聚糖的抗肿瘤、降血糖、增强免疫等活性研究逐渐增多, 研究发现海洋动物糖胺聚糖可以抑制S180肿瘤细胞生长, 促进T、B淋巴细胞增殖, 增强NK细胞活性, 清除O2-?、?OH、DPPH?自由基, 降低血清总胆固醇(total cholesterol, TC)、低密度脂蛋白(low density lipoprotein, LDL)和甘油三酯(triglyceride, TG)的含量, 升高高密度脂蛋白 (high density lipoprotein, HDL)水平, 促进胆固醇代谢。这些特性都将使海洋动物糖胺聚糖成为医学及保健品行业重点研究对象, 使得一些海洋动物得以高值化利用, 促进海洋经济发展。本文主要对海洋动物中糖胺聚糖的研究现状、结构分类、提取方法、分离纯化、分析测定和生物活性进行了概述。
Glycosaminoglycans were found in the tissue of most marine animals, which were extracted by enzymatic method. Seven kinds of glycosaminoglycans have been identified. In recent years, due to their high biological activities and low toxicity, experts worldwide were attracted by the anti-tumor, lowering blood glu-cose, immuno-enhancement effects of glycosaminoglycans from marine animals. Researches indicated that glycosaminoglycans of marine animal can inhibit the growth of S180 tumor cells, promote proliferation of T and B lymphocytes, enhance the activity of NK cells, scavenge free radicalof O2-?,?OH and DPPH?, reduce content of serum total cholesterol, low density lipoprotein and triglyceride , increase the level of high density lipoprotein, promote the metabolism of cholesterol. These features of glycosaminoglycans have attracted attention from medicine and health products industry. Marine animals can be utilized for high value, and promote the development of marine economy. This review summarized the research status and progress of glycosaminoglycans from marine animal, including structure classification, extraction method, separation analysis, analytical determination and physiological activities.
标题：海洋动物糖胺聚糖的研究进展
英文标题：Research progress of glycosaminoglycans from marine animals
作者：
周小双 中国水产科学研究院南海水产研究所,农业部水产品加工重点实验室,国家水产品加工技术研发中心,上海海洋大学食品学院
王锦旭 中国水产科学研究院南海水产研究所,农业部水产品加工重点实验室,国家水产品加工技术研发中心
杨贤庆 中国水产科学研究院南海水产研究所,农业部水产品加工重点实验室,国家水产品加工技术研发中心
魏涯 中国水产科学研究院南海水产研究所,农业部水产品加工重点实验室,国家水产品加工技术研发中心
中文关键词:海洋动物,糖胺聚糖,结构分析,分离纯化,生物活性,
英文关键词:marine animals, glycosaminoglycan, structure classification, separation and purification, biological activities,
发表日期：2015-11-04
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