Objective To redefine the form of food aluminum (water-soluble and monolayer liposome affinity) after entering the human body, and investigate the dissolution rate of food aluminum (vermicelli and lasagna) in the gastrointestinal tract and the ratio of its migration into the systemic circulation system (bioavailability). Methods The migration and distribution of aluminum from foods in human body were studied with an in vitro biomimetic digestion model. Digestion and absorption in the gastrointestinal tract were simulated by bionic gastrointestinal digestion and bionic biomembrane absorption with liposome. Results The dissolution rate of aluminum in the gastrointestinal tract was 31.0%~42.5%, in which, the rate of the affinity-liposome Al accounted for 69.4%~76.8%. Conclusion Aluminum has a bioaccessibility and bioavailability adapted to the food matrix and in vivo environment of human body, which could not be simply replaced by the total amount of aluminum in food. As a result, both the dissolution rate and the bioavailability of aluminum from food in the digestion system should be simultaneously taken into account for the establishment of the provisional tolerable weekly intake of aluminum.
标题：仿生研究食品中铝的体内迁移分配及其生物利用率评价
英文标题：Study of migration and distribution of aluminum from foods by in vitro biomimetic digestion and bioavailability assessment
