复方牛磺酸维生素饮料缓解小鼠体力疲劳作用研究
目的 研究复方牛磺酸维生素饮料缓解小鼠体力疲劳的作用。方法 将200只健康雄性ICR小鼠分成4组, 第1组负重游泳, 第2组测肝糖原和肝脏丙二醛(hepatic malondialdehyde, MDA), 第3组测高尿素模型小鼠血清尿素氮(urea nitrogen, UREA)、乳酸脱氢酶(lactate dehydrogenase, LDH)、肝脏MDA, 第4组测血乳酸(blood lactic acid, BLA), 每组50只, 组内按体重分成去离子水阴性对照组、糖水对照组、3个复方牛磺酸维生素饮料剂量组[3.33、6.67、20.00 mL/(kg·d) 6.25倍浓缩液]。各组连续灌胃30 d后, 分别检测小鼠负重游泳时间、肝糖原、肝脏MDA、血清UREA、LDH、BLA等疲劳相关的指标。结果 复方牛磺酸维生素饮料对各组小鼠体重无影响(P＞0.05), 在中剂量能显著延长小鼠负重游泳时间(P＜0.05), 显著增加小鼠肝糖原含量(P＜0.05), 显著降低高尿素模型小鼠血清LDH(P＜0.01), 在高剂量能显著降低高尿素模型小鼠血清中UREA(P＜0.01)、血清LDH(P＜0.05)、肝脏MDA含量(P＜0.05), 对BLA曲线下面积无影响(P＞0.05)。结论 此配方的复方牛磺酸维生素饮料对ICR小鼠具有缓解体力疲劳的功能。
Objective To study the effect of compound taurine vitamin drink on alleviating physical fatigue in mice. Methods A total of 200 healthy male ICR mice were divided into 4 batches. The first batch was used to detect the loading swimming time. The second batch was used to detect the hepatic glycogen, hepatic MDA. The third batch was used to detect the UREA, LDH and hepatic MDA of the high UREA model mice, and the fourth batch was used to detect the BLA. Each batch (50 mice) was randomly divided into deionized water control group, sugar control group and 3 compound taurine vitamin drink dosage groups [3.33, 6.67, 20.00 mL/(kg·d) 6.25 times concentrated solution] according to the body weights. After continual intragastric administration for 30 days, the time of weight-loading swimming, hepatic glycogen, MDA, UREA, LDH, and BLA were detected. Results The sample had no significant influence on the body weight in mice (P＞0.05). The middle dosage group could efficiently extend the time of weight-loading swimming (P<0.05), increase the hepatic glycogen content of mice (P<0.05), and reduce the LDH content of high UREA model mice (P<0.01). The high dosage group could significantly reduce the UREA (P<0.01), LDH (P<0.05) and MDA (P<0.05) content of high UREA model mice. It had no significant influence on the area under curve of the BLA (P＞0.05). Conclusion This drink recipe has the effect of alleviating physical fatigue in mice.
标题：复方牛磺酸维生素饮料缓解小鼠体力疲劳作用研究
英文标题：Effect of compound taurine vitamin drink on alleviating physical fatigue in mice
作者：
郑立新 中国检验检疫科学研究院综合检测中心,国家质检总局毒理重点实验室
吴玉平 中国检验检疫科学研究院综合检测中心,国家质检总局毒理重点实验室
蔡祥焜 中国检验检疫科学研究院综合检测中心,国家质检总局毒理重点实验室
杨彩玲 中国检验检疫科学研究院综合检测中心,国家质检总局毒理重点实验室
魏长垒 中国检验检疫科学研究院综合检测中心,国家质检总局毒理重点实验室
田世民 中国检验检疫科学研究院综合检测中心,国家质检总局毒理重点实验室
中文关键词:复方牛磺酸,维生素饮料,小鼠,缓解体力疲劳,
英文关键词:compound taurine,vitamin drink,mice,alleviate physical fatigue,
发表日期：2019-12-04
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