低钠高钾饮食干预对高血压患者NO、ET-1水平及动脉僵硬度的影响
目的 探究低钠高钾饮食干预对高血压患者一氧化氮(nitric oxide, NO)、内皮素-1(endothelin-1, ET-1)水平及动脉僵硬度的影响。方法 选取2016年10月~2017年10月我院收治的高血压患者98例, 随机将研究对象分为对照组与研究组, 2组患者均进行常规降压治疗, 其中对照组患者42例给予普通饮食, 而研究组患者56例则给予低钠高钾饮食干预。在饮食干预一年后, 观察比较2组患者在干预前后的血清NO、ET-1水平、血压情况以及动脉僵硬度。结果 干预前, 2组患者的SBP、DBP、血清NO、ET-1水平、以及CAVI水平经比较差异均无统计学意义(P＞0.05); 干预后, 研究组患者的SBP与DBP水平均较对照组更低(P＜0.05), 研究组患者的血清NO水平高于对照组, ET-1水平低于对照组(P＜0.05), 且研究组患者的CAVI水平也低于对照组(P＜0.05), 差异存在统计学意义。结论 低钠高钾饮食干预可一定程度的改善高血压患者的血清NO、ET-1水平, 降低血压, 缓解动脉僵硬度, 保护患者的血管内皮功能。
Objective To analyze the effects of low-sodium and high-potassium diet intervention on nitric oxide (NO), endothelin-1 (ET-1) levels and arterial stiffness in hypertensive patients. Methods Totally 98 patients with hypertension admitted to our hospital from October 2016 to October 2017 were randomly divided into the control group and the study group. Both groups were treated with conventional antihypertensive therapy. Among them, 42 patients in the control group were given a normal diet, while 56 patients in the study group were given a low-sodium and high-potassium diet. One year after dietary intervention, serum NO, ET-1 levels, blood pressure, and arterial stiffness were compared between the 2 groups before and after intervention. Results There were no significant differences in SBP, DBP, serum NO, ET-1 levels, and CAVI levels between the 2 groups (P>0.05) before intervention. After intervention, the SBP and DBP levels, ET-1 levels, and CAVI levels in the study group were lower than those in the control group (P<0.05), and the serum NO level in the study group was higher than that in the control group (P<0.05), the differences were statistically significant. Conclusion The intervention of low-sodium and high-potassium diet can improve the levels of serum NO and et-1 in patients with hypertension to a certain extent, reduce blood pressure, relieve arterial stiffness, and protect the vascular endothelial function of patients.
标题：低钠高钾饮食干预对高血压患者NO、ET-1水平及动脉僵硬度的影响
英文标题：Effect of low-sodium and high-potassium diet intervention on NO, ET-1 levels and arterial stiffness in patients with hypertension
作者：
高天芳 昆山市第二人民医院心血管科
许元青 昆山市第二人民医院心血管科
中文关键词:高血压,低钠高钾饮食,一氧化氮,内皮素-1,动脉僵硬度,
英文关键词:hypertension,low-sodium and high-potassium diet,nitric oxide,endothelin-1,arterial stiffness,
发表日期：2019-01-16
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