超高压液相色谱-串联质谱法对马口铁罐内涂层中双酚A及其模拟迁移的测定
目的 建立了超高压液相色谱-串联质谱法测定马口铁罐内涂层中双酚A迁移含量的方法。方法 样品经模拟溶液提取后以C18色谱柱分离, UPLC-MS/MS多反应监测模式下进行定性定量分析, 对金属制品内涂层双酚A在不同食品模拟物环境下的迁移行为进行了研究。结果 线性范围为5.0~100.0 μg/L, 最低检测浓度为1.0 μg/L, 回收率为78.6%~85.9%, 相对标准偏差为7.30%~12.60%。结论 双酚A迁移水平受模拟物性质影响, 相对于水性模拟物, 在醇溶性模拟物中更易发生迁移。双酚A迁移水平随迁移试验温度和接触时间的增加而升高。
Objective An ultra high pressure liquid chromatography (UHPLC)-mass spectrometry/mass spectrometry (MS/MS) method has been established for determination of bisphenol A (BPA) migration content in coating tinplate tank. Methods The different simulation extraction solutions were separated with C18 chromatographic column, and were qualitatively and quantitatively analyzed with UPLC-MS/MS analysis method. The migration behavior of free BPA in metal food packaging material in different food simulation solution was studied. Results The method linear range was 5.0~100.0 μg/L, the minimum detection concentration was 1.0 μg/L, the recovery was 78.6%~78.6%, and the relative standard deviation was 7.30%~12.60%. Conclusion The migration behavior of BPA is affected by the nature of simulation solution properties. Compared with water-based analog, the more migration will be ℃curred in alcohol-soluble simulation solution. The migration level of BPA will be increased with the elevated temperature and a long period of contaction.
标题：超高压液相色谱-串联质谱法对马口铁罐内涂层中双酚A及其模拟迁移的测定
英文标题：Determination of bisphenol A migration from inside coating of tinplate can by ultra perssure liquid chromatography-tandem mass spectrometry
作者：
张旭龙 新疆出入境检验检疫局技术中心
田延河 新疆出入境检验检疫局
全小盾 新疆出入境检验检疫局
刘俊 新疆出入境检验检疫局
中文关键词:超高压液相色谱-串联质谱法,双酚A,马口铁罐,迁移,测定,
英文关键词:ultra high pressure liquid chromatography-tandem mass spectrometry,bisphenol A,tinplate cans,mi-gration,determination,
发表日期：2013-06-04
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