气相色谱-质谱法测定婴幼儿配方乳粉及原料中 15 种邻苯二甲酸酯

气相色谱-质谱法测定婴幼儿配方乳粉及原料中 15 种邻苯二甲酸酯
目的   建立婴幼儿配方乳粉及原料中 15 种邻苯二甲酸酯的气相色谱-质谱检测方法。 方法   样品经乙腈提取后,  用 GC-MS 检测。采用外标法进行定量分析。结果   15 种邻苯二甲酸酯的线性范围除了邻苯二甲酸二异壬酯为 0.01~1 mg/L,  其余均为 0.001~1 mg/L,  相关系数大于 0.99。方法检出限(S/N=3)为 0.006~0.2 mg/kg, 定量限(S/N=10)为 0.02～0.7 mg/kg。 在奶粉基质中 3 个加标水平的平均回收率在 88.6%~117.2%,  相对标准偏差为 1.0%~9.3%。结论   本方法操作简单、精确、快速、廉价、稳定,  适用于奶粉中邻苯二甲酸酯类化合物的检测分析。

Objective   To establish a method for the determination of phthalic acid esters in infant formula milk powder and raw materials by gas chromatography-mass spectrometry (GC-MS). Methods  Samples were extracted with acetonitrile, and then detected by GC-MS. The external standard method was conducted for the quantitative analysis. Results    The linear range of 15 phthalic acid esters were 0.001~1 mg/L, except that the linear range of phthalate isononyl ester was 0.01~1 mg/L with R>0.99. LOD (S/N=3) and LOQ(S/N=10) were 0.006~0.2 mg/kg and 0.02~0.7 mg/kg, respectively. The recoveries were 88.6%~117.2% at three spiked level with relative standard deviation of 1.0%~9.3%. Conclusion    This method is simple, accurate, fast, cheap and stable, and it is suitable for the detection of phthalic acid esters in milk powder.

标题：气相色谱-质谱法测定婴幼儿配方乳粉及原料中 15 种邻苯二甲酸酯
英文标题：Determination of 15 phthalic acid esters in infant formula milk powder and raw material by gas chromatography-mass spectrometry

作者：
杨国良 浙江省贝因美科工贸股份有限公司
孔福奎 浙江省贝因美科工贸股份有限公司
张开祥 浙江省贝因美科工贸股份有限公司
赖世云 浙江省贝因美科工贸股份有限公司
任一平 浙江省疾病预防控制中心

中文关键词:气相色谱-质谱,邻苯二甲酸酯,婴幼儿配方乳粉,
英文关键词:gas chromatography-mass spectrometry,phthalic acid esters,infant formula milk powder,

发表日期：2013-05-22

气相色谱-质谱法测定婴幼儿配方乳粉及原料中 15 种邻苯二甲酸酯.pdf

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