超高效液相色谱–质谱联用法定量测定奶茶中的 3种毒品成分
超高效液相色谱–质谱联用法定量测定奶茶中的 3种毒品成分
目的建立超高效液相色谱质谱联用法测定奶茶中苯丙胺、甲基苯丙胺和氯胺酮的分析方法。 方法样品经甲醇超声提取处理, 利用超高效液相色谱质谱联用法, 4.0 min内完成样品的上机分析。结果方法在0.1~50.0 ng/mL范围内, 线性良好, 相关系数r大于0.999。仪器检出限在0.008~0.027 ng/mL之间, 定量限在0.028~0.089 ng/mL之间。三水平加标回收率在80.7%~112.0%之间。高浓度样品分析后, 3种毒品无明显仪器残留。使用本方法分析市售奶茶样品, 未检出3种毒品。结论本方法灵敏、快速、线性范围宽、选择性好、前处理简单, 适用于奶茶中3种毒品的准确定量检测。
ObjectiveTo establish a method for determining amphetamine, methamphetamine and ketamine in milk tea by ultra performance liquid chromatography-tandem mass spectrometry. MethodsThe sample was ultrasonically extracted by methanol, utilizing ultra performance liquid chromatography-mass spectrometry, the sample analysis of the sample was completed within 4.0 min. ResultsIn the range of 0.1?50.0 ng/mL, the linearity was good, and the correlation coefficient r was greater than 0.999. The limit of detection of the instrument was in 0.008?0.027 ng/mL, and the limit of quantification was in 0.028?0.089 ng/mL. The recoveries rate of the 3 levels was in 80.7%?112.0%. After analyzing the high-concentration samples, there were no obvious instrument residues in the 3 drugs. The method was used to analyze commercially available milk tea samples, and the 3 drugs were not detected. ConclusionThis method is sensitive, rapid, wide in linear range, good in selectivity, simple in pretreatment, and suitable for accurate quantitative detection of 3 drugs in milk tea.
标题：超高效液相色谱–质谱联用法定量测定奶茶中的 3种毒品成分
英文标题：Quantitative determination of 3 related narcotic substances in milk teaby ultra performance liquid chromatography-tandemmass spectrometry
作者：
余晓琴 四川省食品药品检验检测院
李澍才 四川省食品药品检验检测院
中文关键词:奶茶,毒品,超高效液相色谱法,三重四极杆质谱法,
英文关键词:milk tea,narcotic substances,ultra performance liquid chromatography,triple quadrupole mass spectrometry,
发表日期：2019-06-24
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