黄曲霉毒素B1致肝脏损伤作用机制的研究进展
黄曲霉毒素B1致肝脏损伤作用机制的研究进展
黄曲霉毒素B1(aflatoxin B1, AFB1)是一种毒性极强的真菌毒素, 也是诱发肝癌的重要危险因素之一。AFB1与乙肝病毒两者协同致癌作用比单因素乙肝病毒诱发肝癌高约30~60倍。AFB1进入体内后主要通过引发DNA损伤发挥毒性作用, 其中DNA-加合物是最常见的损伤形式, 而表观遗传修饰的改变在其致肝脏损伤中也发挥着显著的作用。本文综述了近年来AFB1致肝脏损伤的相关研究进展, 总结出AFB1可能的致癌机制, 以期为防治黄曲霉毒素引起的肝脏损伤提供理论依据。
Aflatoxin B1 (AFB1) is a highly toxic mycotoxin and one of the important risk factors for liver cancer. The synergistic carcinogenic effect of AFB1 and hepatitis B virus is about 30-60 times higher than that of single-factor hepatitis B virus-induced liver cancer. AFB1 plays a toxic role in body mainly by triggering DNA damage, DNA-adduct is the most common form of damage, and changes in epigenetic modification play a significant role in liver damage. This paper reviewed recent advances in AFB1-induced liver injury, and summarized the possible carcinogenic mechanisms of AFB1 to provide a theoretical basis for the prevention and treatment of liver damage caused by aflatoxin.
标题：黄曲霉毒素B1致肝脏损伤作用机制的研究进展
英文标题：Research progress on the mechanism of liver damage induced by aflatoxin B1
作者：
师文文 海军军医大学海军医学系防化医学教研室
姜凯 中国人民解放军第医院
徐庆强 海军军医大学海军医学系防化医学教研室
孟文琪 海军军医大学海军医学系防化医学教研室
孙铭学 海军军医大学海军医学系防化医学教研室
赵杰 海军军医大学海军医学系防化医学教研室
肖凯 海军军医大学海军医学系防化医学教研室
中文关键词:黄曲霉毒素B1,DNA损伤,表观遗传修饰,肝脏损伤,
英文关键词:aflatoxin B1,DNA damage,epigenetic modification,liver damage,
发表日期：2018-09-10
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